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There is growing awareness that the profound environmental changes (eg, in diet and other lifestyle conditions) that began with the introduction of agriculture and animal husbandry ≈10000 y ago occurred too recently on an evolutionary time scale for the human genome to adapt (2-5).Initially, when permanent environmental changes occur in a population, individuals bearing the previous average status quo genome experience evolutionary discordance (2, 3).In the affected genotype, this evolutionary discordance manifests itself phenotypically as disease, increased morbidity and mortality, and reduced reproductive success (1-3).Some female startup founders speak up about behavior they say they encounter in the male-dominated venture capital industry, as a string of scandals prompt some in the industry to confront cases of impropriety and re-examine practices. Fowler offers some ways to make smartphones, laptops and i Pads less frustrating for seniors and the people who love them.Tech often fails seniors, and it isn’t their fault. In a world of overstuffed inboxes and constant beeping texts, phone calls have never been so precious. Joanna Stern explains all the ways you can make a call today.

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